Research

Image Guided Cryoablation

Image Guided Cryoablation of Cancer with Intra-Tumor Injection of anti-CTLA-4 and PD-1 Immune Checkpoint Inhibitors.

Jason R. Williams MD | Patrick E. Sewell MD | Mark A. Rosenberg MD

Ablation Mechanisms

Thermal ablation of tumours; biological mechanisms and advances in therapy.

Katrina F. Chu and Damian E. Dupuy

Ablation Vaccine

Saponin-based adjuvants create a highly effective anti-tumor vaccine when combined with in situ tumor destruction.

Martijn H. den Brok, Stefan Nierkens, Jori A. Wagenaars, Theo J. Ruers, Carla C. Schrier, Eric O. Rijke, Gosse J. Adema

CpG Cryo Dendritic

In vivo Colocalization of Antigen and CpG within Dendritic Cells Is Associated with the Efficacy of Cancer Immunotherapy.

Stefan Nierkens, Martijn H. den Brok, Roger P.M. Sutmuller, Oliver M. Grauer, Erik Bennink, Mary E. Morgan, Carl G. Figdor, Theo J.M. Ruers, and Gosse J. Adema

DIPP4T Cell Trafficking

Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy.

Rosa Barreira da Silva, Melissa E Laird, Nader Yatim, Laurence Fiette, Molly A Ingersoll & Matthew L Albert

Intratumoral CTLA4

Intratumoral Anti-CTLA-4 Therapy: Enhancing Efficacy While Avoiding Toxicity.

Aurélien Marabelle, Holbrook Kohrt, and Ronald Levy

Intratumoral Immunization

Intratumoral Immunization: A New Paradigm for Cancer Therapy

Aurélien Marabelle, Holbrook Kohrt, Christophe Caux, et al.

Local CTLA4 Injection

Controlled Local Delivery of CTLA-4 Blocking Antibody Induces CD8þ T-Cell–Dependent Tumor Eradication and Decreases Risk of Toxic Side Effects

Marieke F. Fransen, Tetje C. van der Sluis, Ferry Ossendorp, Ramon Arens, and Cornelis J.M. Melief

Low Dose Cyclophosphimide

Cyclophosphamide Unmasks an Antimetastatic Effect of Local Tumor Cryoablation.

Moshe Yair Levy, Abhinav Sidana, Wasim H. Chowdhury, Steven B. Solomon, Charles G. Drake, Ronald Rodriguez, and Ephraim J. Fuchs